High-performance liquid chromatography (HPLC) also know as high-pressure liquid chromatography is an instrumental system based on chromatography that is widely used in forensic science. The “HP” portion of the acronym is sometimes assigned to the words high pressure (versus high performance), but it refers to the same analytical system. HPLC is used in drug analysis, toxicology, explosives analysis, ink analysis, fibers, and plastics to name a few forensic applications.